Impact of observational incompleteness on the structural properties of protein interaction networks

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Mathias Kuhnt - , TUD Dresden University of Technology, Siemens AG (Author)
  • Ingmar Glauche - , Leipzig University (Author)
  • Martin Greiner - , Siemens AG (Author)

Abstract

The observed structure of protein interaction networks is corrupted by many false positive/negative links. This observational incompleteness is abstracted as random link removal and a specific, experimentally motivated (spoke) link rearrangement. Their impact on the structural properties of gene-duplication-and-mutation network models is studied. For the degree distribution a curve collapse is found, showing no sensitive dependence on the link removal/rearrangement strengths and disallowing a quantitative extraction of model parameters. The spoke link rearrangement process moves other structural observables, like degree correlations, cluster coefficient and motif frequencies, closer to their counterparts extracted from the yeast data. This underlines the importance to take a precise modeling of the observational incompleteness into account when network structure models are to be quantitatively compared to data.

Details

Original languageEnglish
Pages (from-to)759-769
Number of pages11
JournalPhysica A: Statistical Mechanics and its Applications
Volume373
Publication statusPublished - 1 Jan 2007
Peer-reviewedYes

External IDs

ORCID /0000-0002-2524-1199/work/153110194

Keywords

Keywords

  • Complex networks, Network structure, Noise, Protein-protein-interaction networks