Impact of contact inhibition on collective cell migration and proliferation

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Contact inhibition limits migration and proliferation of cells in cell colonies. We consider a multiphase field model to investigate the growth dynamics of a cell colony, composed of proliferating cells. The model takes into account the mechanism of contact inhibition of proliferation by local mechanical interactions. We compare nonmigrating and migrating cells, in order to provide a quantitative characterization of the dynamics and analyze the velocity of the colony boundary for both cases. Additionally, we measure single cell velocities, number of neighbor distributions, as well as the influence of stress and age on positions of the cells and with respect to each other.

Details

Original languageEnglish
Article number034402
Number of pages9
JournalPhysical Review E
Volume2022
Issue number105(3)
Publication statusPublished - Mar 2022
Peer-reviewedYes

External IDs

PubMed 35428163