Imaging-based treatment adaptation in radiation oncology
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
In many tumor types, significant effort is being put into patienttailored adaptation of treatment to improve outcome and preferably reduce toxicity. These opportunities first arose with the introduction of modern irradiation techniques (e.g., intensity-modulated radiotherapy) combined with functional imaging for more precise delineation of target volume. On the basis of functional CT, MRI, and PET results, radiation target volumes are altered during the course of treatment, or subvolumes inside the primary tumor are defined to enhance the dosing strategy. Moreover, the probability of complications to normal tissues is predicted using anatomic or functional imaging, such as in the use of CT or PET to predict radiation pneumonitis. Besides focusing, monitoring, and adapting photon therapy for solid tumors, PET also has a role in verifying protonbeam therapy. This article discusses the current state and remaining challenges of imaging-based treatment adaptation in radiation oncology.
Details
Original language | English |
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Pages (from-to) | 1922-1929 |
Number of pages | 8 |
Journal | Journal of Nuclear Medicine |
Volume | 56 |
Issue number | 12 |
Publication status | Published - 1 Dec 2015 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 26429959 |
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Keywords
ASJC Scopus subject areas
Keywords
- Functional CT, Functional MRI, PET/CT, Theranostics