Identification of new gene candidates on the sex chromosomes of the platyfish Xiphophorus maculatus

Research output: Contribution to journalResearch articleContributedpeer-review


  • Astrid Boehne - (Author)
  • Christina Schultheis - (Author)
  • Qingchun Zhou - (Author)
  • Alexander Froschauer - , University of Würzburg (Author)
  • Cornelia Schmidt - (Author)
  • Yvonne Selz - (Author)
  • Ingo Braasch - (Author)
  • Catherine Ozouf-Costaz - (Author)
  • Agnes Dettai - (Author)
  • Beatrice Segurens - (Author)
  • Arnaud Couloux - (Author)
  • Sylvie Bernard-Samain - (Author)
  • Stefan Chilmonczyk - (Author)
  • Alia Gannouni - (Author)
  • Karim Madani - (Author)
  • Frederic Brunet - (Author)
  • Delphine Galiana-Arnoux - (Author)
  • Manfred Schartl - (Author)
  • Jean-Nicolas Volff - (Author)


In order to better understand the molecular and evolutionary mechanisms driving sex determination in fish, bacterial artificial chromosome (BAC) contigs covering the sex determination region of the X and Y sex chromosomes of the platyfish Xiphophorus maculatus have been constructed. Initial analysis of these contigs led to the identification of eleven gene candidates closely linked to the master sex-determining locus and expressed in different types of tissues. These genes are all present on both the X and the Y chromosomes, suggesting a restricted degree of differentiation and probably a young evolutionary age for the platyfish sex chromosomes. Syntenies were detected with several zebrafish chromosomes as well as with two medaka and several tetrapod autosomes, supporting an independent origin of sex chromosomes not only in different vertebrate lineages but also in different fish species.


Original languageEnglish
Pages (from-to)067-071
JournalCybium : international journal of ichthyology
Issue number2
Publication statusPublished - Jul 2008
Externally publishedYes

External IDs

Scopus 69249135841


Library keywords