Identification of doublestranded genomic dna spanning all chromosomes with mutated KRAS and P53 DNA in the serum exosomes of patients with pancreatic cancer

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Christoph Kahlert - , University of Texas at Austin, Heidelberg University  (Author)
  • Sonia A. Melo - , University of Texas at Austin (Author)
  • Alexei Protopopov - , University of Texas at Austin (Author)
  • Jiabin Tang - , University of Texas at Austin (Author)
  • Sahil Seth - , University of Texas at Austin (Author)
  • Moritz Koch - , Department of Visceral, Thoracic and Vascular Surgery (Author)
  • Jianhua Zhang - , University of Texas at Austin (Author)
  • Juergen Weitz - , Department of Visceral, Thoracic and Vascular Surgery (Author)
  • Lynda Chin - , Heidelberg University , University of Texas at Austin (Author)
  • Andrew Futreal - , University of Texas at Austin (Author)
  • Raghu Kalluri - , University of Texas at Austin (Author)

Abstract

Background: Exosomes are small vesicles in the tumor microenvironment containing nucleic acids and proteins with the capacity to influence cell behavior. Results: Exosomes contain double-stranded genomic DNA. Conclusion: Exosomes have the capacity to carry and transport genomic DNA spanning all chromosomes with KRAS and p53 mutations. Significance: Exosomes can aid in identifying genomic mutations in patients with pancreatic cancer.

Details

Original languageEnglish
Pages (from-to)3869-3875
Number of pages7
JournalJournal of Biological Chemistry
Volume289
Issue number7
Publication statusPublished - 14 Feb 2014
Peer-reviewedYes

External IDs

PubMed 24398677

Keywords

Sustainable Development Goals

ASJC Scopus subject areas