Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Harriet Dempsey-Jones - , University of Oxford (Author)
  • Susann Steudte-Schmiedgen - , Department of Psychotherapy and Psychosomatic Medicine (Author)
  • Michael Browning - , University of Oxford (Author)
  • Tamar R Makin - , University of Oxford (Author)
  • Marcella L Woud - , Ruhr University Bochum (Author)
  • Catherine J Harmer - , University of Oxford (Author)
  • Juergen Margraf - , Ruhr University Bochum (Author)
  • Andrea Reinecke - , University of Oxford (Author)

Abstract

BACKGROUND: The optimisation of learning has long been a focus of scientific research, particularly in relation to improving psychological treatment and recovery of brain function. Previously, partial N-methyl-D-aspartate agonists have been shown to augment reward learning, procedural learning and psychological therapy, but many studies also report no impact of these compounds on the same processes.

AIMS: Here we investigate whether administration of an N-methyl-D-aspartate partial agonist (D-cycloserine) modulates a previously unexplored process - tactile perceptual learning. Further, we use a longitudinal design to investigate whether N-methyl-D-aspartate-related learning effects vary with time, thereby providing a potentially simple explanation for apparent mixed effects in previous research.

METHODS: Thirty-four volunteers were randomised to receive one dose of 250 mg D-cycloserine or placebo 2 h before tactile sensitivity training. Tactile perception was measured using psychophysical methods before and after training, and 24/48 h later.

RESULTS: The placebo group showed immediate within-day tactile perception gains, but no further improvements between-days. In contrast, tactile perception remained at baseline on day one in the D-cycloserine group (no within-day learning), but showed significant overnight gains on day two. Both groups were equivalent in tactile perception by the final testing - indicating N-methyl-D-aspartate effects changed the timing, but not the overall amount of tactile learning.

CONCLUSIONS: In sum, we provide first evidence for modulation of perceptual learning by administration of a partial N-methyl-D-aspartate agonist. Resolving how the effects of such compounds become apparent over time will assist the optimisation of testing schedules, and may help resolve discrepancies across the learning and cognition domains.

Details

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalJournal of Psychopharmacology
Volume35
Issue number3
Publication statusPublished - Mar 2021
Peer-reviewedYes

External IDs

PubMedCentral PMC7924109
Scopus 85100998249
ORCID /0000-0002-1171-7133/work/142255041

Keywords

Keywords

  • Adolescent, Adult, Cognition/drug effects, Cycloserine/pharmacology, Double-Blind Method, Drug Partial Agonism, Female, Humans, Learning/drug effects, Longitudinal Studies, Male, Receptors, N-Methyl-D-Aspartate/agonists, Time Factors, Touch Perception/drug effects, Young Adult