Human Adult Neurogenesis: Evidence and Remaining Questions

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Gerd Kempermann - , Chair of Genomics of Regeneration, Center for Regenerative Therapies Dresden, German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association), TUD Dresden University of Technology (Author)
  • Fred H. Gage - , Salk Institute for Biological Studies (Author)
  • Ludwig Aigner - , Paracelsus Private Medical University (Author)
  • Hongjun Song - , University of Pennsylvania (Author)
  • Maurice A. Curtis - , The University of Auckland (Author)
  • Sandrine Thuret - , King's College London (KCL) (Author)
  • H. Georg Kuhn - , University of Gothenburg, Charité – Universitätsmedizin Berlin (Author)
  • Sebastian Jessberger - , University of Zurich (Author)
  • Paul W. Frankland - , University of Toronto (Author)
  • Heather A. Cameron - , National Institutes of Health (NIH) (Author)
  • Elizabeth Gould - , Princeton University (Author)
  • Rene Hen - , Columbia University (Author)
  • D. Nora Abrous - , Université de Bordeaux (Author)
  • Nicolas Toni - , University of Lausanne (Author)
  • Alejandro F. Schinder - , Consejo Nacional de Investigaciones Científicas y Técnicas (Author)
  • Xinyu Zhao - , University of Wisconsin-Madison (Author)
  • Paul J. Lucassen - , University of Amsterdam (Author)
  • Jonas Frisén - , Karolinska Institutet (Author)

Abstract

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

Details

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalCell Stem Cell
Volume23
Issue number1
Publication statusPublished - 5 Jul 2018
Peer-reviewedYes

External IDs

PubMed 29681514
ORCID /0000-0002-5304-4061/work/142238815

Keywords