High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis –TREATgermany registry analysis

Research output: Contribution to journalResearch articleContributedpeer-review


  • Hannover Medical School (MHH)
  • Kiel University
  • Practice Dr. med. Konstantin Ertner
  • Elbe Klinikum Buxtehude
  • Heidelberg University 
  • Ludwig Maximilian University of Munich
  • Bielefeld University
  • Helix Medical Ecellence Center Mainz
  • Dermatology at Lesum
  • Practice Dr. med. Julia Wildberger
  • Practice Dr. med. Franca Wiemers
  • Hautambulatorium Magdeburg


Background: Eczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort. Methods: We sought to investigate the TREATgermany cohort, a multicenter, non-interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH. Results: Of the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patients with EH, 107 had multiple EH (54.9%), representing 12.0% of the total study population. While there were no differences in demographic characteristics, previous treatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patients with EH had more frequent atopic comorbidities and sensitizations to house dust mite, food, and mold. Discussion: TREATgermany registry data suggest a high prevalence and recurrence rate of EH, while there appears to be no specific clinical phenotype, besides an increase in allergies, to identify EH patients in the daily routine.


Original languageEnglish
Pages (from-to)1490-1498
Number of pages9
JournalJDDG - Journal of the German Society of Dermatology
Issue number12
Early online date15 Sept 2023
Publication statusPublished - Dec 2023

External IDs

ORCID /0000-0002-4049-9120/work/150329941
ORCID /0000-0001-7457-6481/work/150329769
PubMed 38082531
Scopus 85179302010
Scopus 85173659028


ASJC Scopus subject areas


  • Atopic dermatitis, herpes simplex, registry, Humans, Eczema, Skin Diseases, Dermatitis, Atopic/drug therapy

Library keywords