HIF and MYC signaling in adrenal neoplasms of the neural crest: implications for pediatrics
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Pediatric neural crest-derived adrenal neoplasms include neuroblastoma and pheochromocytoma. Both entities are associated with a high degree of clinical heterogeneity, varying from spontaneous regression to malignant disease with poor outcome. Increased expression and stabilization of HIF2α appears to contribute to a more aggressive and undifferentiated phenotype in both adrenal neoplasms, whereas MYCN amplification is a valuable prognostic marker in neuroblastoma. The present review focuses on HIF- and MYC signaling in both neoplasms and discusses the interaction of associated pathways during neural crest and adrenal development as well as potential consequences on tumorigenesis. Emerging single-cell methods together with epigenetic and transcriptomic analyses provide further insights into the importance of a tight regulation of HIF and MYC signaling pathways during adrenal development and tumorigenesis. In this context, increased attention to HIF-MYC/MAX interactions may also provide new therapeutic options for these pediatric adrenal neoplasms.
Details
Original language | English |
---|---|
Article number | 1022192 |
Journal | Frontiers in endocrinology |
Volume | 14 |
Publication status | Published - 8 Jun 2023 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC10286580 |
---|---|
Scopus | 85163610613 |
ORCID | /0000-0002-6932-333X/work/142239674 |
WOS | 001012461800001 |
Mendeley | 3957b9a9-c0c8-363d-b1b2-7ca241353c45 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Humans, Child, Proto-Oncogene Proteins c-myc/metabolism, Neural Crest/metabolism, Signal Transduction/genetics, Adrenal Gland Neoplasms/metabolism, Neuroblastoma/metabolism, Carcinogenesis/metabolism, Pheochromocytoma, Sympathoadrenal cell lineage, Paraganglioma, Catecholamines, Neuroblastoma, Neural crest, Myc, Hypoxia, hypoxia, catecholamines, sympathoadrenal cell lineage, neural crest, neuroblastoma, pheochromocytoma, paraganglioma, MYC