Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

Jimmy Masjkur - , Department of Internal Medicine III (Author)
Carina Arps-Forker - , TUD Dresden University of Technology (Author)
Steven W. Poser - , TUD Dresden University of Technology (Author)
Polyxeni Nikolakopoulou - , TUD Dresden University of Technology (Author)
Louiza Toutouna - , TUD Dresden University of Technology (Author)
Ramu Chenna - , Technology Platform BIOTEC (Author)
Triantafyllos Chavakis - , Institute of Clinical Chemistry and Laboratory Medicine (Author)
Antonios Chatzigeorgiou - , Institute for Clinical Chemistry and Laboratory Medicine (Author)
Lan Sun Chen - , Institute for Clinical Chemistry and Laboratory Medicine (Author)
Anna Dubrovska - , OncoRay - National Center for Radiation Research in Oncology, Department of Internal Medicine III (Author)
Pratik Choudhary - , King's College London (KCL) (Author)
Ingo Uphues - , Boehringer Ingelheim GmbH (Author)
Michael Mark - , Boehringer Ingelheim GmbH (Author)
Stefan R. Bornstein - , Department of Internal Medicine III (Author)
Andreas Androutsellis-Theotokis - , TUD Dresden University of Technology (Author)

Background: The transcription factor Hes3 regulates the growth of neural and brain cancer stem cells.

Results: Hes3 regulates growth, gene expression, evoked insulin release in cultured insulinoma cells, and sensitivity to streptozotocin in vivo.

Conclusion: Hes3 is a novel regulator of cellular functions of importance in diabetes.

Original language	English
Pages (from-to)	35503-35516
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	51
Publication status	Published - 19 Dec 2014
Peer-reviewed	Yes