Hemispheric asymmetry in cortical thinning reflects intrinsic organization of the neurotransmitter systems and homotopic functional connectivity

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Zhijie Liao - , University Hospital Centre Sainte-Justine (CHUSJ) (Author)
  • Tobias Banaschewski - , Heidelberg University (Author)
  • Arun L W Bokde - , Trinity College Dublin (Author)
  • Sylvane Desrivières - , King's College Hospital NHS Foundation Trust (Author)
  • Herta Flor - , Heidelberg University, University of Mannheim (Author)
  • Antoine Grigis - , Commissariat à l’énergie atomique et aux énergies alternatives (Author)
  • Hugh Garavan - , Northern Vermont University (Author)
  • Penny Gowland - , Nottingham Trent University (Author)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Bernd Ittermann - , Physikalisch-Technische Bundesanstalt (Author)
  • Jean-Luc Martinot - , INSERM - Institut national de la santé et de la recherche médicale (Author)
  • Marie-Laure Paillère Martinot - , Pitié-Salpêtrière Hospital (Author)
  • Eric Artiges - , Etablissement Public de Santé (EPS) Barthélemy Durand (Author)
  • Frauke Nees - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Dimitri Papadopoulos Orfanos - , Commissariat à l’énergie atomique et aux énergies alternatives (Author)
  • Luise Poustka - , University Medical Center Göttingen (Author)
  • Sarah Hohmann - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Sabina Millenet - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Juliane H Fröhner - , Department of Psychiatry and Psychotherapy (Author)
  • Michael N Smolka - , Department of Psychiatry and Psychotherapy (Author)
  • Henrik Walter - , Charité – Universitätsmedizin Berlin (Author)
  • Robert Whelan - , Trinity College Dublin (Author)
  • Gunter Schumann - , Zhongshan Hospital at Fudan University (Author)
  • Tomáš Paus - , University Hospital Centre Sainte-Justine (CHUSJ) (Author)

Abstract

Hemispheric lateralization and its origins have been of great interest in neuroscience for over a century. The left-right asymmetry in cortical thickness may stem from differential maturation of the cerebral cortex in the two hemispheres. Here, we investigated the spatial pattern of hemispheric differences in cortical thinning during adolescence, and its relationship with the density of neurotransmitter receptors and homotopic functional connectivity. Using longitudinal data from IMAGEN study (N = 532), we found that many cortical regions in the frontal and temporal lobes thinned more in the right hemisphere than in the left. Conversely, several regions in the occipital and parietal lobes thinned less in the right (vs. left) hemisphere. We then revealed that regions thinning more in the right (vs. left) hemispheres had higher density of neurotransmitter receptors and transporters in the right (vs. left) side. Moreover, the hemispheric differences in cortical thinning were predicted by homotopic functional connectivity. Specifically, regions with stronger homotopic functional connectivity showed a more symmetrical rate of cortical thinning between the left and right hemispheres, compared with regions with weaker homotopic functional connectivity. Based on these findings, we suggest that the typical patterns of hemispheric differences in cortical thinning may reflect the intrinsic organization of the neurotransmitter systems and related patterns of homotopic functional connectivity.

Details

Original languageEnglish
Article numbere2306990120
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America : PNAS
Volume120
Issue number42
Publication statusPublished - 17 Oct 2023
Peer-reviewedYes

External IDs

PubMedCentral PMC10589642
Scopus 85174850838
ORCID /0000-0001-5398-5569/work/150329564
ORCID /0000-0002-8493-6396/work/150330263

Keywords

Keywords

  • Adolescent, Humans, Brain Mapping, Cerebral Cortical Thinning, Neural Pathways/physiology, Magnetic Resonance Imaging, Functional Laterality/physiology, Receptors, Neurotransmitter, Brain/physiology