In Germany as well as in most Western industrialized countries, the work-force is rapidly "aging". Modern companies therefore increasingly need to abandon established approaches to occupational safety and pursue preventive strategies to protect and restore well-being, work ability, and good health across the entire lifespan. Hence, effective occupational health management needs to encompass strategic work and career designs. In response to these challenges, an interdisciplinary group of researchers at the Jacobs Center on Lifelong Learning and Institutional Development of the Jacobs University Bremen has zoomed in on two concepts that have so far received little attention in research on occupational health management; namely, person-environment fit and work-task mobility. Person-environment fit refers to the fit between individuals (e.g., abilities, behaviors, goals, attitudes) and their work environments (e.g., job profile, demands, support structures, culture). Work-task mobility refers to careers involving repeated intra-organizational changes of work tasks at the same level of job complexity (no promotion or demotion). This chapter reports on two research projects, Demopass and Mobilis, that aim to investigate person-environment fit and work-task mobility, respectively, as two important tools for systemic and dynamic occupational health management in times of demographic change.