Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Research output: Contribution to journalShort survey/reviewContributedpeer-review

Contributors

  • Eric E. Smith - , University of Calgary (Author)
  • Geert Jan Biessels - , Utrecht University (Author)
  • François De Guio - , Université Paris Cité (Author)
  • Frank Erik de Leeuw - , Radboud University Nijmegen (Author)
  • Simon Duchesne - , Université Laval (Author)
  • Marco Düring - , Ludwig Maximilian University of Munich, German Center for Neurodegenerative Diseases (DZNE), Munich Cluster for Systems Neurology (SyNergy) (Author)
  • Richard Frayne - , University of Calgary , Foothills Medical Centre (Author)
  • M. Arfan Ikram - , Erasmus University Rotterdam (Author)
  • Eric Jouvent - , Université Paris Cité (Author)
  • Bradley J. MacIntosh - , University of Toronto (Author)
  • Michael J. Thrippleton - , University of Edinburgh (Author)
  • Meike W. Vernooij - , Erasmus University Rotterdam (Author)
  • Hieab Adams - , Erasmus University Rotterdam (Author)
  • Walter H. Backes - , Maastricht University Medical Centre (UMC+) (Author)
  • Lucia Ballerini - , University of Edinburgh (Author)
  • Sandra E. Black - , University of Toronto, Heart and Stroke Foundation of Canada (Author)
  • Christopher Chen - , National University of Singapore (Author)
  • Rod Corriveau - , National Institutes of Health (NIH) (Author)
  • Charles DeCarli - , University of California at Davis (Author)
  • Steven M. Greenberg - , Harvard University (Author)
  • M. Edip Gurol - , Harvard University (Author)
  • Michael Ingrisch - , Ludwig Maximilian University of Munich (Author)
  • Dominic Job - , University of Edinburgh (Author)
  • Bonnie Y.K. Lam - , Chinese University of Hong Kong (Author)
  • Lenore J. Launer - , National Institutes of Health (NIH) (Author)
  • Jennifer Linn - , Institute and Polyclinic of Diagnostic and Interventional Neuroradiology, University Hospital Carl Gustav Carus Dresden (Author)
  • Cheryl R. McCreary - , University of Calgary , Foothills Medical Centre (Author)
  • Vincent C.T. Mok - , Chinese University of Hong Kong (Author)
  • Leonardo Pantoni - , University of Milan (Author)
  • G. Bruce Pike - , University of Calgary (Author)
  • Joel Ramirez - , University of Toronto (Author)
  • Yael D. Reijmer - , Utrecht University (Author)
  • Jose Rafael Romero - , Boston University, National Institutes of Health (NIH) (Author)
  • Stefan Ropele - , Medical University of Graz (Author)
  • Natalia S. Rost - , Harvard University (Author)
  • Perminder S. Sachdev - , University of New South Wales (Author)
  • Christopher J.M. Scott - , University of Toronto (Author)
  • Sudha Seshadri - , University of Texas Health Science Center at San Antonio (Author)
  • Mukul Sharma - , McMaster University (Author)
  • Steven Sourbron - , University of Leeds (Author)
  • Rebecca M.E. Steketee - , Erasmus University Rotterdam (Author)
  • Richard H. Swartz - , University of Toronto (Author)
  • Robert van Oostenbrugge - , Maastricht University Medical Centre (UMC+) (Author)
  • Matthias van Osch - , Leiden University (Author)
  • Sanneke van Rooden - , Leiden University (Author)
  • Anand Viswanathan - , Harvard University (Author)
  • David Werring - , University College London (Author)
  • Martin Dichgans - , Ludwig Maximilian University of Munich, German Center for Neurodegenerative Diseases (DZNE), Munich Cluster for Systems Neurology (SyNergy) (Author)
  • Joanna M. Wardlaw - , University of Edinburgh (Author)

Abstract

Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

Details

Original languageEnglish
Pages (from-to)191-204
Number of pages14
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
Publication statusPublished - Dec 2019
Peer-reviewedYes

Keywords

Sustainable Development Goals

Keywords

  • Cerebrovascular disease, Dementia, Magnetic resonance imaging, Radiology, Stroke