Grundlagen der Pharmakologie von Lokalanästhetika

Research output: Contribution to journalReview articleContributedpeer-review


The development of local anesthetics revolutionized the performance of painful interventions. Local anesthetics have an effect on voltage-gated sodium channels in nerve fibers and modulate the conduction of impulses. With respect to the chemical structure, local anesthetics can be divided into amide and ester types. The structural differences of local anesthetics have an influence on the duration of action, the degradation pathways and specific side effects. Severe adverse events include cardiotoxicity and neurotoxicity. In addition to basic measures, such as the monitoring and securing of vital parameters, lipid infusion represents a treatment option in cases of intoxication. The recent developments of local anesthetics are particularly concerned with the reduction of toxicity and prolonging the duration of action.

Translated title of the contribution
Principles of the pharmacology of local anesthetics


Original languageGerman
Pages (from-to)204-220
Number of pages17
JournalDie Anaesthesiologie : Zeitschrift für Anästhesie, Intensivmedizin, Notfall- und Katastrophenmedizin, Schmerztherapie
Issue number3
Early online date13 Feb 2024
Publication statusPublished - 13 Feb 2024

External IDs

ORCID /0000-0001-8494-1403/work/153655074
Scopus 85185131021



  • Amides/pharmacology, Anesthetics, Local/adverse effects, Humans, Nerve Fibers, Pain