Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

Research output: Contribution to journalReview articleContributedpeer-review


  • Qingfang Han - , Shandong University, University of Jinan (Author)
  • Jinbo Pang - , Shandong University (Author)
  • Yufen Li - , Shandong University (Author)
  • Baojun Sun - , Shandong University, University of Jinan (Author)
  • Bergoi Ibarlucea - , Chair of Materials Science and Nanotechnology, Center for Advancing Electronics Dresden (cfaed) (Author)
  • Xiaoyan Liu - , Shandong University (Author)
  • Thomas Gemming - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • Qilin Cheng - , Shandong University (Author)
  • Shu Zhang - , Shandong University (Author)
  • Hong Liu - , Shandong University (Author)
  • Jingang Wang - , Shandong University (Author)
  • Weijia Zhou - , Shandong University (Author)
  • Gianaurelio Cuniberti - , Chair of Materials Science and Nanotechnology, Center for Advancing Electronics Dresden (cfaed), Max Bergmann Center of Biomaterials Dresden (Author)
  • Mark H. Rümmeli - , Leibniz Institute for Solid State and Materials Research Dresden, Soochow University, Polish Academy of Sciences, VŠB – Technical University of Ostrava (Author)


The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.


Original languageEnglish
Pages (from-to)3841-3881
Number of pages41
JournalACS sensors
Issue number11
Publication statusPublished - 26 Nov 2021

External IDs

PubMed 34696585
ORCID /0000-0002-9899-1409/work/142249205


Sustainable Development Goals


  • biodevices, biomarker detection, circulating tumor cells, early diagnosis, electrochemical biosensors, field-effect transistors, functionalization, graphene, microfluidic system, optical biosensors

Library keywords