Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes

Research output: Contribution to journalComment/debateInvitedpeer-review



Over the past decade, researchers have made substantial progress in characterizing a network of mononuclear phagocytes in the kidney, which variously have been referred to as resident macrophages or dendritic cells. Two recent studies, published in Cell and Kidney International, have identified these resident macrophages/dendritic cells as local immune monitors of peritubular capillaries for circulating antigens and immune complexes. These cells appear to represent an early line of defense against circulating infectious particles and immune complexes, but the resulting inflammatory response may also contribute to interstitial inflammation and kidney disease progression.


Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalKidney International
Issue number2
Publication statusPublished - Feb 2017

External IDs

Scopus 85034051938
PubMed 28087004
ORCID /0000-0001-6287-9725/work/146644980
ORCID /0000-0002-9728-1413/work/146646213



  • Antigen-Antibody Complex, Dendritic Cells/immunology, Humans, Kidney/immunology, Kidney Diseases, Macrophages/immunology, Phagocytes/immunology