Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes
Research output: Contribution to journal › Comment/debate › Invited › peer-review
Contributors
Abstract
Over the past decade, researchers have made substantial progress in characterizing a network of mononuclear phagocytes in the kidney, which variously have been referred to as resident macrophages or dendritic cells. Two recent studies, published in Cell and Kidney International, have identified these resident macrophages/dendritic cells as local immune monitors of peritubular capillaries for circulating antigens and immune complexes. These cells appear to represent an early line of defense against circulating infectious particles and immune complexes, but the resulting inflammatory response may also contribute to interstitial inflammation and kidney disease progression.
Details
Original language | English |
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Pages (from-to) | 267-269 |
Number of pages | 3 |
Journal | Kidney International |
Volume | 91 |
Issue number | 2 |
Publication status | Published - Feb 2017 |
Peer-reviewed | Yes |
External IDs
Scopus | 85034051938 |
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PubMed | 28087004 |
ORCID | /0000-0001-6287-9725/work/146644980 |
ORCID | /0000-0002-9728-1413/work/146646213 |
Keywords
Keywords
- Antigen-Antibody Complex, Dendritic Cells/immunology, Humans, Kidney/immunology, Kidney Diseases, Macrophages/immunology, Phagocytes/immunology