Genomic aberrations in myeloid sarcoma without blood or bone marrow involvement: Characterization of formalin-fixed paraffin-embedded samples by chromosomal microarrays

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • M. Kamran Mirza - , The University of Chicago (Author)
  • Madina Sukhanova - , The University of Chicago (Author)
  • Friedrich Stölzel - , Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden (Author)
  • Kenan Onel - , The University of Chicago (Author)
  • Richard A. Larson - , The University of Chicago (Author)
  • Wendy Stock - , The University of Chicago (Author)
  • Gerhard Ehninger - , University Hospital Carl Gustav Carus Dresden, Department of internal Medicine I (Author)
  • Friederike Kuithan - , University Hospital Carl Gustav Carus Dresden, Institute of Pathology (Author)
  • Klaus Zöphel - , University Hospital Carl Gustav Carus Dresden, Department of Nuclear Medicine (Author)
  • Poluru Reddy - , The University of Chicago (Author)
  • Loren Joseph - , The University of Chicago (Author)
  • Gordana Raca - , The University of Chicago (Author)

Abstract

Myeloid sarcoma (MS) is a presentation of acute myeloid leukemia (AML) as a tumor mass outside of the bone marrow. Viable cells from MS are frequently unavailable for cytogenetic studies. We therefore investigated whether chromosomal microarray analysis (CMA) using formalin-fixed paraffin-embedded (FFPE) tissues can detect clinically important genetic abnormalities in MS. CMA successfully identified genomic aberrations in six cases of MS, and in two cases it revealed multiple abnormalities equivalent to a complex karyotype, thus predicting a poor outcome. CMA using FFPE material is therefore a feasible and clinically applicable approach for detection of prognostically significant genomic abnormalities in MS.

Details

Original languageEnglish
Pages (from-to)1091-1096
Number of pages6
JournalLeukemia research
Volume38
Issue number9
Publication statusPublished - Sept 2014
Peer-reviewedYes

External IDs

PubMed 25088808

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • Chromosomal microarrays, Cytogenetics, Myeloid sarcoma