Functional significance of adult neurogenesis

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Gerd Kempermann - , Charité – Universitätsmedizin Berlin (Author)
  • Laurenz Wiskott - , Humboldt University of Berlin (Author)
  • Fred H. Gage - , Salk Institute for Biological Studies (Author)

Abstract

'Function' is the key criterion for determining whether adult neurogenesis - be it endogenous, induced, or after transplantation - is successful and has truly generated new nerve cells. Function, however, is an elusive and problematic term. A satisfying statement of function will require evaluation on the three conceptual levels of cells, networks, and systems - and potentially even beyond, on the level of psychology. Neuronal development is a lengthy process, a fact that must be considered when judging causes and consequences in experiments that address function and function-dependent regulation of adult neurogenesis. Nevertheless, the information that has been obtained and published so far provides ample evidence that neurons generated in the adult can function and even suggests how they might contribute to cognitive processes.

Details

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume14
Issue number2
Publication statusPublished - Apr 2004
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 15082323
ORCID /0000-0002-5304-4061/work/152544200

Keywords

ASJC Scopus subject areas

Keywords

  • SGZ, Subgranular zone