Receptor tyrosine kinases (RTKs) serve as cell surface receptors for peptide ligands and are central for regulating processes such as cell proliferation, apoptosis, migration, and differentiation. RTK signaling pathways lead to diverse cellular responses although converging on a relatively confined set of highly conserved core signaling processes.^1,2 Our knowledge of RTK signaling networks advances with increasing pace, but our understanding of how specific cell fate decisions are orchestrated lags behind and deterministic modeling of RTK signaling is missing so far. Surprisingly, the fact that crucial initial activation steps occur at the membrane itself is still greatly underestimated, although accumulating evidence suggests a functional role of membrane lipids directly involved in regulating receptor signaling.^3–5.