Functional dextran amino acid ester particles derived from N-protected S-trityl-L-cysteine
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
This work describes the derivatization of dextran using N-(tert-butyloxycarbonyl)-S-(trityl)-L-cysteine in the presence of N,N'-carbonyldiimidazole (CDI) as a coupling agent. Homogeneous reactions in dimethyl sulfoxide allowed for an efficient coupling of the amino acid derivative to the polymer backbone. Derivatization was confirmed by infrared and C-13 NMR spectroscopy, size exclusion chromatography and elemental analysis. The presence of hydrophobic protecting groups resulted in a product that can be shaped into water-insoluble particles stable in an aqueous environment and non-toxic for lung epithelial cells. It is suggested that materials composed of ester bonds between amino acids and polysaccharides are useful for targeted drug delivery, bioimaging or surface functionalization.
Details
Original language | English |
---|---|
Pages (from-to) | 561-566 |
Number of pages | 6 |
Journal | Colloids and Surfaces B: Biointerfaces |
Volume | 181 |
Publication status | Published - 1 Sept 2019 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
Scopus | 85066940446 |
---|
Keywords
Keywords
- Dextran, Bio-Conjugation, Micro-/nano-particles, Emulsion precipitation, Cytotoxicity, Zeta-Potential, DRUG-DELIVERY, NANOPARTICLES, DERIVATIVES