Functional convergence of hopanoids and sterols in membrane ordering
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Liquid-ordered phases are one of two biochemically active membrane states, which until now were thought to be a unique consequence of the interactions between eukaryotic membrane lipids. The formation of a liquid-ordered phase depends crucially on the ordering properties of sterols. However, it is not known whether this capacity exists in organisms that lack sterols, such as bacteria. We show that diplopterol, the simplest bacterial hopanoid, has similar properties and that hopanoids are bacterial "sterol surrogates" with the ability to order saturated lipids and to form a liquid-ordered phase in model membranes. These observations suggest that the evolution of an ordered biochemically active liquid membrane could have evolved before the oxygenation of Earth's surface and the emergence of sterols.
Details
Original language | English |
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Pages (from-to) | 14236-14240 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America : PNAS |
Volume | 109 |
Issue number | 35 |
Publication status | Published - 28 Aug 2012 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC3435179 |
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Scopus | 84865532003 |
ORCID | /0000-0001-8901-4377/work/142232427 |
Keywords
Keywords
- Bacteria/metabolism, Cell Membrane/chemistry, Cholesterol/chemistry, Evolution, Molecular, Lipid A/chemistry, Lipid Bilayers/chemistry, Liposomes/chemistry, Membrane Lipids/chemistry, Models, Chemical, Sphingomyelins/chemistry, Sterols/chemistry, Terpenes/chemistry, Triterpenes/chemistry