Medical knowledge spans over a large scope (e.g., from the single cell to the whole human body). Hence, finding orientation between science and daily practice in health care is not an easy task. There is a vast amount of literature regarding knowledge and its transfer. The article presents a framework in order to structure methods of knowledge exchange and transfer corresponding to different levels of the healthcare system-societal, organizational, and group level. This framework will support the selection of knowledge management methods, IT support, and architectural means discussed in order to support the transfer of knowledge in hospitals and in the healthcare system.