Flexible Polymer Optical Waveguides for Integrated Optogenetic Brain Implants

Research output: Contribution to book/Conference proceedings/Anthology/Report › Conference contribution › Contributed › peer-review

Contributors

  • Julian A. Singer - , Hamburg University of Technology (Author)
  • Till Stramm - , Dortmund University of Technology (Author)
  • Jens Fasel - , Dortmund University of Technology (Author)
  • Oliver Schween - , Dortmund University of Technology (Author)
  • Anton Gelaeschus - , Hamburg University of Technology (Author)
  • Andreas Bahr - , Hamburg University of Technology, Kiel University (Author)
  • Matthias Kuhl - , University of Freiburg (Author)

Abstract

This paper presents a manufacturing process for flexible optical waveguides made of biocompatible polydimethylsiloxane (PDMS) to be attached to future optogenetic implants. Based on a complementary metal-oxide-semiconductor (CMOS) application-specific integrated circuit (ASIC), the system uses integrated single photon avalanche diodes (SPADs) as sensors for fluorescence imaging (FI) and post-CMOS micro light-emitting diodes (µLEDs) for stimulation [1]. Attaching fibers to SPADs and µLEDs to collect and distribute light from and to deeper brain layers can unfold previously unachieved medical applications. Two technologies for biocompatible waveguide manufacturing are presented: thin-film and molding. Such a combination of integrated bidirectional implantable ASICs with custom waveguide manufacturing is not limited to medical scenarios but opens up a broad field of applications.

Details

Original languageEnglish
Title of host publication2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages370-373
Number of pages4
ISBN (electronic)978-1-6654-9308-6
ISBN (print)978-1-6654-9309-3
Publication statusPublished - 19 Jan 2023
Peer-reviewedYes
Externally publishedYes

Publication series

SeriesIEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN1084-6999

Conference

Title36th IEEE International Conference on Micro Electro Mechanical Systems
Abbreviated titleMEMS 2023
Conference number36
Duration15 - 19 January 2023
Website
LocationScience Congress Center Munich
CityGarching bei München
CountryGermany

External IDs

Scopus 85149877211
ORCID /0000-0001-8012-6794/work/184006552

Keywords

ASJC Scopus subject areas

Keywords

  • Biomedical optical imaging, Optical fiber sensors, Optical fibers, Optical imaging, Optogenetics, Sensor systems and applications, Stimulated emission, ASIC, biomedical, brain implants, integrated circuits, MEMS, molding, neural implants, optogenetics, polymer, SPAD, thin-film, waveguide, μLED