Flexible, large-area, and distributed sensor and/or actuator array closely contacted with the human skin are human-friendly and sophisticated tools for biomedical and healthcare applications. In this paper, new applications and design solutions in organic electronics are shown. In an insole pedometer with piezoelectric energy harvesters, an all-pMOS negative voltage generator for a pseudo-CMOS inverter is shown. In a surface electromyogram measurement sheet for the prosthetic hand control, a post-fabrication select-and-connect method to reduce the transistor mismatch is shown. In a flexible wet sensor sheet to detect the urination in diapers, ESD protection with organic schottky diodes is shown.