Fatal hepatic necrosis after isoflurane anaesthesia

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • J. Weitz - , Heidelberg University  (Author)
  • P. Kienle - , Heidelberg University  (Author)
  • H. Böhrer - , Heidelberg University  (Author)
  • W. Hofmann - , Heidelberg University  (Author)
  • L. Theilmann - , Heidelberg University  (Author)
  • G. Otto - , Heidelberg University  (Author)

Abstract

Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti-trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.

Details

Original languageEnglish
Pages (from-to)892-895
Number of pages4
JournalAnaesthesia
Volume52
Issue number9
Publication statusPublished - Sept 1997
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 9349074

Keywords

ASJC Scopus subject areas

Keywords

  • Anaesthetics, volatile; isoflurane, Complications; death, Liver; toxicity