Fast and reliable reduced-order models for cardiac electrophysiology

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Sridhar Chellappa - , Max Planck Institute for Dynamics of Complex Technical Systems (First author)
  • Baris Cansiz - , Chair of Structural Analysis (Author)
  • Lihong Feng - , Max Planck Institute for Dynamics of Complex Technical Systems (Author)
  • Peter Benner - , Max Planck Institute for Dynamics of Complex Technical Systems (Author)
  • Michael Kaliske - , Chair of Structural Analysis (Author)

Abstract

Mathematical models of the human heart increasingly play a vital role in understanding the working mechanisms of the heart, both under healthy functioning and during disease. The ultimate aim is to aid medical practitioners diagnose and treat the many ailments affecting the heart. Towards this, modeling cardiac electrophysiology is crucial as the heart's electrical activity underlies the contraction mechanism and the resulting pumping action. Apart from modeling attempts, the pursuit of efficient, reliable, and fast solution algorithms has been of great importance in this context. The governing equations and the constitutive laws describing the electrical activity in the heart are coupled, nonlinear, and involve a fast moving wave front, which is generally solved by the finite element method. The numerical treatment of this complex system as part of a virtual heart model is challenging due to the necessity of fine spatial and temporal resolution of the domain. Therefore, efficient surrogate models are needed to predict the electrical activity in the heart under varying parameters and inputs much faster than the finely resolved models. In this work, we develop an adaptive, projection-based reduced-order surrogate model for cardiac electrophysiology. We introduce an a posteriori error estimator that can accurately and efficiently quantify the accuracy of the surrogate model. Using the error estimator, we systematically update our surrogate model through a greedy search of the parameter space. Furthermore, using the error estimator, the parameter search space is dynamically updated such that the most relevant samples get chosen at every iteration. The proposed adaptive surrogate model is tested on three benchmark models to illustrate its efficiency, accuracy, and ability of generalization.

Details

Original languageEnglish
Article numbere202370014
Number of pages25
JournalGAMM Mitteilungen
Volume46 (2023)
Issue number3-4
Publication statusPublished - 16 Jan 2024
Peer-reviewedYes

External IDs

Scopus 85181231467

Keywords

Sustainable Development Goals

Keywords

  • cardiac electrophysiology, error estimation, model order reduction