FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Megan Bowers - , University of Zurich (Author)
  • Tong Liang - , University of Zurich (Author)
  • Daniel Gonzalez-Bohorquez - , University of Zurich (Author)
  • Sara Zocher - , German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association), Center for Regenerative Therapies Dresden (Author)
  • Baptiste N. Jaeger - , University of Zurich (Author)
  • Werner J. Kovacs - , ETH Zurich (Author)
  • Clemens Röhrl - , Medical University of Vienna (Author)
  • Kaitlyn M.L. Cramb - , University of Zurich (Author)
  • Jochen Winterer - , University of Zurich (Author)
  • Merit Kruse - , University of Zurich (Author)
  • Slavica Dimitrieva - , ETH Zurich (Author)
  • Rupert W. Overall - , TUD Dresden University of Technology (Author)
  • Thomas Wegleiter - , University of Zurich (Author)
  • Hossein Najmabadi - , University of Social Welfare and Rehabilitation Sciences (Author)
  • Clay F. Semenkovich - , Washington University St. Louis (Author)
  • Gerd Kempermann - , Center for Regenerative Therapies Dresden, German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Csaba Földy - , University of Zurich (Author)
  • Sebastian Jessberger - , University of Zurich (Author)

Abstract

Using mouse and human tissue genome engineering, Bowers et al. show that a human variant in fatty acid synthase (FASN) provides a link between altered lipid metabolism, neurogenic stem/progenitor activity, and brain function.

Details

Original languageEnglish
Pages (from-to)98-109.e11
JournalCell Stem Cell
Volume27
Issue number1
Publication statusPublished - 2 Jul 2020
Peer-reviewedYes

External IDs

PubMed 32386572
ORCID /0000-0002-5304-4061/work/142238796

Keywords

ASJC Scopus subject areas

Keywords

  • cognition, disease modeling, genome editing, hippocampus, intellectual disability, learning, lipid metabolism, neural stem cell, neurogenesis, organoid

Library keywords