Failure of autologous fresh frozen plasma to reduce blood loss and transfusion requirements in coronary artery bypass surgery

Research output: Contribution to journalResearch articleContributedpeer-review


  • Stefan Mario Kasper - , University of Cologne (Author)
  • Thorsten Giesecke - , University of Cologne (Author)
  • Peter Limpers - , Krankenhaus Porz am Rhein (Author)
  • Rainer Sabatowski - , University of Cologne (Author)
  • Uwe Mehlhorn - , University of Cologne (Author)
  • Christoph Diefenbach - , University of Cologne (Author)


Background: Previous studies failed to demonstrate any benefit from prophylaxis with fresh frozen plasma (FFP) after cardiopulmonary bypass (CPB). The results, however, were limited by either retrospective study design or use of FFP in subtherapeutic doses (2-3 units). The authors evaluated whether a therapeutic dose (15 ml/kg) of FFP reduces blood loss and transfusion requirements in elective coronary artery bypass surgery. The risks of multiple allogeneic blood donor exposure were circumvented by using autologous plasma. Methods: Sixty adult patients scheduled for elective primary coronary artery bypass grafting were randomized to receive, after CPB, an intravenous infusion of 15 ml/kg of either autologous FFP (30 patients) or 6% hydroxyethyl starch 450/0.7 (HES; 30 patients). Autologous plasma was obtained by platelet-poor plasmapheresis several weeks before surgery. Perioperative blood transfusions were administered per protocol. Post-operative blood loss was defined as the chest tube drainage during the first 24 h after surgery. Results: The data from 56 patients (FFP group, 27 patients; HES group, 29 patients) who completed the study according to protocol were analyzed. Median postoperative blood loss was 630 ml (range, 450-1,840 ml) and 830 ml (range, 340-1,980 ml) in the FFP and HES groups, respectively (P = 0.08). Both post-operative (0-24 h) and total perioperative erythrocyte transfusion requirements did not differ significantly between the groups (P = 0.32 and 0.14, respectively). Conclusion: The prophylactic administration of a therapeutic dose (15 ml/kg) of autologous FFP after CPB failed to reduce blood loss and transfusion requirements in patients undergoing uncomplicated, elective, primary coronary artery bypass surgery.


Original languageEnglish
Pages (from-to)81-86
Number of pages6
Issue number1
Publication statusPublished - 2001
Externally publishedYes

External IDs

PubMed 11465588


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