Extracytoplasmic function σ factors come of age

Research output: Contribution to journalResearch articleContributedpeer-review



Bacterial signal transduction involves one- and two-component systems and extracytoplasmic function σ factors. With its simple design, the one-component system is the most widely distributed type of bacterial signal transduction system. The design of two-component systems simplifies transmembrane signaling and also enables many modifications, including amplification and integration of different signals. The activity of ECF σ-factors is regulated by different mechanisms through a diverse set of anti- σ molecules. Although the two-component system and ECF σ factors are phylogenetically and biochemically unrelated, they share several mechanistic analogies while differing in the way their respective two-protein components communicate with each other.


Original languageEnglish
Pages (from-to)164-170
Number of pages7
Journal Microbe : the news magazine of the American Society for Microbiology
Issue number4
Publication statusPublished - Apr 2010


ASJC Scopus subject areas