Providing care for people living with dementia includes considering the impact of the architectural design of their environments on the person’s physical-social-mental well-being. Designs that support physical function and take into account sensory loss lessen the stress on the mind and lower the distress experienced by persons with dementia. Acute illness, requiring hospitalization, is known to lead to considerable distress and behaviors that can lead to lower physical and mental function. One solution is for architects and interior designers of these facilities to follow the design principles postulated for dementia-friendly architecture. Emerging dementia-friendly designs of (health) care facilities create supportive environments for everyone, including visitors and staff. In the future, designs will also need to accommodate the challenges and changes that lay ahead, with buildings that perform well to disasters, disruptions, and adverse events. By elucidating the design answers to demographic change, climate change, and recurring epidemics, it is shown that following dementia-friendly design criteria contributes to building resilient structures for the future.KeywordsDementiaLong-term care (LTC)HospitalArchitectureResilience