Exit from the trans-Golgi network: From molecules to mechanisms

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Mihaela Anitei - (Author)
  • Bernard Hoflack - , Dresden University of Technology (Author)

Abstract

The trans-Golgi network is a major sorting platform of the secretory pathway from which proteins and lipids, both newly synthesized and retrieved from endocytic compartments, are targeted to different destinations. These sorting processes occur during the formation of pleomorphic tubular-vesicular carriers. The past years have provided insights into basic mechanisms coordinating the spatial and temporal organization of machineries necessary for the segregation of membrane components into distinct microdomains, for the bending, elongation, and fission of corresponding membranes, thus revealing a complex interplay of protein-protein and protein-lipid interactions.

Details

Original languageEnglish
Pages (from-to)443-451
Number of pages9
JournalCurrent opinion in cell biology
Volume23
Issue number4
Publication statusPublished - Aug 2011
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 21550789

Keywords

ASJC Scopus subject areas