Since the beginning of the intentional production of alcoholic beverages more than 10.000 years ago, drinking has become an integral part of human life, but also a major contributor to increased morbidity and mortality. In search of the mechanisms underlying excessive alcohol consumption, the prefrontal cortex has been shown to play a key role in controlling goal-directed actions and inhibition of inappropriate behaviours and appears to be highly vulnerable to the effects of alcohol. Here, we evaluated how different alcohol consumption patterns impact prefrontal neural networks by recording electrophysiological brain activity directly from the surface of the medial prefrontal cortex of rats using a 3D-printed neuroprosthetic interface. In awake animals, we acquired auditory event-related potentials and oscillatory activity related to perceptual processes and higher-order cognitive functioning. Recordings were conducted in sober, alcohol-naïve animals and after acute administration of ethanol at a moderate dose (1.5g/kg) reflecting the average consumption by an adult on a night out, e.g. three glasses of beer, and a high dose (3g/kg) corresponding to heavy binge drinking. Further recordings were performed in animals with access to alcohol for >1 year, reflecting chronic consumption patterns observed in alcohol addiction. Moderate ethanol induced a slightly tottering gait and neural changes limited to a more pronounced N2 amplitude and thus a later peaking P3 component. High-dose alcohol, however, completely immobilised the animals, diminished all but the P1 component and reduced overall oscillatory activity, indicating deficits in the entire information processing system. Chronic alcohol consumption induced similar impairments as observed after high-dose acute alcohol, even after weeks of abstinence. Additionally, higher-beta frequency and gamma activity dominated, indicating an overaroused neural state prone to relapse. While neural effects of moderate consumption seem manageable, these results underline the devastating effects of both, binge drinking and chronic alcohol intake, on cognitive processing. Therefore, think’n’drink! Declaration of Interest Statement: None