Erratum: Correction to "Cell-Free Gene Expression Dynamics in Synthetic Cell Populations" (ACS synthetic biology (2022) 11 1 DOI: 10.1021/acssynbio.1c00376)

Research output: Contribution to specialist publicationCorrections (errata and retractions)peer-review

Contributors

  • David T. Gonzales - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Naresh Yandrapalli - , Max Planck Institute of Colloids and Interfaces (Author)
  • Tom Robinson - , Max Planck Institute of Colloids and Interfaces (Author)
  • Christoph Zechner - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), TUD Dresden University of Technology, Clusters of Excellence PoL: Physics of Life (Author)
  • T. Y.Dora Tang - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), TUD Dresden University of Technology, Clusters of Excellence PoL: Physics of Life (Author)

Abstract

After publication, we identified an error in the calculation of the likelihood threshold used to determine approximate 95%-confidence intervals from profile likelihoods. The like- lihood-based confidence intervals are estimated as the regions with (Formula Presented), (Table Presented), (Figure Presented). parameters. In our original publication, the factor 1/2 with χ 2(α,df) was omitted in eq 11 and eq S34. Our error resulted in an overestimation of each parameter’s 95%-confidence interval. The maximum likelihood estimates of the parameters themselves were not affected by the mistake. After correcting this in our calculations, the confidence intervals became narrower. In one instance, this caused a parameter, which was previously found to be weakly identifiable, to become identifiable (Kl). All original and corrected items are provided. While the profile likelihoods plotted in Figures S25−S30 and Figure S49 in the Supporting Information were not affected by the mistake, the likelihood thresholds (gray dashed lines) were incorrect. The original and corrected Figures S25−S30 and Figure S49 are provided.

Details

Original languageEnglish
Pages3471-3484
Number of pages14
Volume13
Issue number10
JournalACS synthetic biology
Publication statusPublished - 18 Oct 2024
Peer-reviewedYes
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External IDs

PubMed 39353201