Epigenetic control of myeloid cell differentiation, identity and function

Research output: Contribution to journalReview articleContributed

Contributors

  • Damiana Álvarez-Errico - , Bellvitge Biomedical Research Institute (IDIBELL) (Author)
  • Roser Vento-Tormo - , Bellvitge Biomedical Research Institute (IDIBELL) (Author)
  • Michael Sieweke - , Marseille-Luminy Immunology Center (CIML) (Author)
  • Esteban Ballestar - , Bellvitge Biomedical Research Institute (IDIBELL) (Author)

Abstract

Myeloid cells are crucial effectors of the innate immune response and important regulators of adaptive immunity. The differentiation and activation of myeloid cells requires the timely regulation of gene expression; this depends on the interplay of a variety of elements, including transcription factors and epigenetic mechanisms. Epigenetic control involves histone modifications and DNA methylation, and is coupled to lineage-specifying transcription factors, upstream signalling pathways and external factors released in the bone marrow, blood and tissue environments. In this Review, we highlight key epigenetic events controlling myeloid cell biology, focusing on those related to myeloid cell differentiation, the acquisition of myeloid identity and innate immune memory.

Details

Original languageEnglish
Pages (from-to)7-17
Number of pages11
JournalNature Reviews. Immunology
Volume15
Issue number1
Publication statusPublished - Jan 2015
Peer-reviewedNo
Externally publishedYes

External IDs

Scopus 84925546982

Keywords

Keywords

  • Animals, Cell Differentiation/genetics, Epigenesis, Genetic, Epigenomics, Gene Expression Regulation, Humans, Immunity/genetics, Inflammation/genetics, Myeloid Cells/cytology, Myelopoiesis/genetics, Phenotype