Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Research output: Contribution to journalResearch articleContributedpeer-review


  • ENIGMA-TS Working Group - (Author)
  • Department of Child and Adolescent Psychiatry and Psychotherapy
  • Chair of Molecular Biophysics
  • Indiana University-Purdue University Indianapolis
  • Leibniz University Hannover
  • Max Planck Institute for Human Cognitive and Brain Sciences
  • University of Catania
  • University of Groningen
  • Dresden University of Technology
  • Herlev University Hospital
  • Paris Sorbonne University Abu Dhabi
  • Hospital Universitario Virgen del Rocio
  • University Hospital Aachen
  • University of Bergen
  • Shanghai Research Center for Brain Science and Brain-Inspired Intelligence
  • Medical University of Warsaw
  • University of Lübeck
  • Ludwig Maximilian University of Munich
  • Deakin University
  • Wake Forest School of Medicine
  • Washington University St. Louis
  • University of Southampton
  • Radboud University Medical Center
  • Charité – Universitätsmedizin Berlin
  • University of California at Irvine
  • University of Copenhagen
  • Pitié-Salpêtrière Hospital
  • University of Seville


Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.


Original languageEnglish
Pages (from-to)958688
JournalFrontiers in psychiatry
Publication statusPublished - 2022

External IDs

PubMedCentral PMC9443935
Scopus 85138038855
ORCID /0000-0002-2213-2763/work/142239789
ORCID /0000-0002-1753-7811/work/142248157