Endovascular Treatment for Acute Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Disease

Research output: Contribution to journalReview articleContributedpeer-review


  • Xiaochuan Huo - , Capital Medical University (CMU) (Author)
  • Dapeng Sun - , Capital Medical University (CMU) (Author)
  • Wenhuo Chen - , Fujian Medical University (Author)
  • Hongxing Han - , Linyi People's Hospital (Author)
  • Mohamad Abdalkader - , Boston Medical Center (BMC) (Author)
  • Volker Puetz - , Department of Neurology, Dresden Neurovascular Center, University Hospital Carl Gustav Carus Dresden, Department of Neurology, Dresden Neurovascular Center (Author)
  • Tingyu Yi - , Fujian Medical University (Author)
  • Hao Wang - , Linyi People's Hospital (Author)
  • Raynald Liu - , Capital Medical University (CMU) (Author)
  • Xu Tong - , Capital Medical University (CMU) (Author)
  • Baixue Jia - , Capital Medical University (CMU) (Author)
  • Ning Ma - , Capital Medical University (CMU) (Author)
  • Feng Gao - , Beijing Tiantan Hospital, Capital Medical University (CMU) (Author)
  • Dapeng Mo - , Capital Medical University (CMU) (Author)
  • Bernard Yan - , University of Melbourne (Author)
  • Peter J Mitchell - , Institute and Polyclinic of Diagnostic and Interventional Radiology (Author)
  • Thomas W Leung - , The Chinese University of Hong Kong, Shenzhen (Author)
  • Dileep R Yavagal - , University of Miami Miller School of Medicine (Author)
  • Gregory W Albers - , Stanford Medicine (Author)
  • Vincent Costalat - , CHU Montpellier (Author)
  • Jens Fiehler - , University Hospital Hamburg Eppendorf (Author)
  • Osama O Zaidat - , Mercy Saint Vincent Medical Center (Author)
  • Tudor G Jovin - , Cooper University Hospital (Author)
  • David S Liebeskind - , Dominican University of California (Author)
  • Thanh N Nguyen - , Boston Medical Center (BMC) (Author)
  • Zhongrong Miao - , Capital Medical University (CMU) (Author)


Intracranial atherosclerotic disease (ICAD) is one of the most common causes of acute ischemic stroke worldwide. Patients with acute large vessel occlusion due to underlying ICAD (ICAD-LVO) often do not achieve successful recanalization when undergoing mechanical thrombectomy (MT) alone, requiring rescue treatment, including intra-arterial thrombolysis, balloon angioplasty, and stenting. Therefore, early detection of ICAD-LVO before the procedure is important to enable physicians to select the optimal treatment strategy for ICAD-LVO to improve clinical outcomes. Early diagnosis of ICAD-LVO is challenging in the absence of consensus diagnostic criteria on noninvasive imaging and early digital subtraction angiography. In this review, we summarize the clinical and diagnostic criteria, prediction of ICAD-LVO prior to the procedure, and EVT strategy of ICAD-LVO and provide recommendations according to the current literature.


Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalSeminars in neurology
Issue number3
Publication statusPublished - Jun 2023

External IDs

Scopus 85168273916



  • Humans, Stroke/diagnostic imaging, Thrombectomy/methods, Ischemic Stroke, Treatment Outcome, Retrospective Studies, Intracranial Arteriosclerosis/complications, Endovascular Procedures/methods