Endovascular Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke: An Evolution of Trials

Research output: Contribution to journalReview articleContributedpeer-review



The last decade's progress in demonstrating the clinical benefit of endovascular thrombectomy (EVT) in patients with large vessel occlusion stroke has transformed the paradigm of care for these patients. This review presents the milestones in implementing EVT as standard of care, demonstrates the current state of evidence, provides guidance for identifying the candidate patient for EVT, and highlights unsolved and controversial issues. Ongoing trials investigate broadening of EVT indications for patients who present with large core infarction, adjunctive intra-arterial thrombolysis, medium vessel occlusion, low NIHSS, and tandem occlusion.


Original languageEnglish
Pages (from-to)397-407
Number of pages11
JournalSeminars in neurology
Issue number3
Publication statusPublished - 18 Aug 2023

External IDs

PubMed 37549693
ORCID /0000-0001-7465-8700/work/145223896
ORCID /0000-0001-5258-0025/work/146644921


ASJC Scopus subject areas


  • anterior circulation LVO stroke, clinical trial, large infarct, large ischemic core, mechanical thrombectomy, medium vessel occlusion, outcome, Brain Ischemia, Humans, Endovascular Procedures, Treatment Outcome, Thrombectomy, Ischemic Stroke, Stroke/surgery