Empfehlungen der AG Klinische Geweberegeneration zur Behandlung von Knorpelschäden am Kniegelenk
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
The Working Group of the German Orthopedic and Trauma Society (DGOU) on Tissue Regeneration has published recommendations on the indication of different surgical approaches for treatment of full-thickness cartilage defects in the knee joint in 2004, 2013 and 2016. Based upon new scientific knowledge and new developments, this recommendation is an update based upon the best clinical evidence available. In addition to prospective randomised controlled clinical trials, this also includes studies with a lower level of evidence. In the absence of evidence, the decision is based on a consensus process within the members of the working group.The principle of making decision dependent on defect size has not been changed in the new recommendation either. The indication for arthroscopic microfracturing has been reduced up to a defect size of 2 cm2 maximum, while autologous chondrocyte implantation is the method of choice for larger cartilage defects. Additionally, matrix-augmented bone marrow stimulation (mBMS) has been included in the recommendation for defects ranging from 1 to 4.5 cm2. For the treatment of smaller osteochondral defects, in addition to osteochondral transplantation (OCT), mBMS is also recommended. For larger defects, matrix-augmented autologous chondrocyte implantation (mACI/mACT) in combination with augmentation of the subchondral bone is recommended.
Details
Original language | English |
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Pages (from-to) | 57-64 |
Number of pages | 8 |
Journal | Zeitschrift fur Orthopadie und Unfallchirurgie |
Volume | 161 |
Issue number | 1 |
Publication status | Published - Feb 2023 |
Peer-reviewed | Yes |
External IDs
Scopus | 85148307047 |
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Keywords
Keywords
- Humans, Prospective Studies, Cartilage Diseases/surgery, Orthopedics, Orthopedic Procedures, Knee Joint/surgery, Chondrocytes, Cartilage, Articular/surgery