Electronic dura mater for long-term multimodal neural interfaces

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Ivan R. Minev - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Pavel Musienko - , Swiss Federal Institute of Technology Lausanne (EPFL), RAS - Pavlov Institute of Physiology (Author)
  • Arthur Hirsch - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Quentin Barraud - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Nikolaus Wenger - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Eduardo Martin Moraud - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Jérôme Gandar - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Marco Capogrosso - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Tomislav Milekovic - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Léonie Asboth - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Rafael Fajardo Torres - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Nicolas Vachicouras - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Qihan Liu - , Harvard University (Author)
  • Natalia Pavlova - , Swiss Federal Institute of Technology Lausanne (EPFL), RAS - Pavlov Institute of Physiology (Author)
  • Simone Duis - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Alexandre Larmagnac - , ETH Zurich (Author)
  • Janos Vörös - , ETH Zurich (Author)
  • Silvestro Micera - , Swiss Federal Institute of Technology Lausanne (EPFL), Sant'Anna School of Advanced Studies (Author)
  • Zhigang Suo - , Harvard University (Author)
  • Grégoire Courtine - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)
  • Stéphanie P. Lacour - , Swiss Federal Institute of Technology Lausanne (EPFL) (Author)

Abstract

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

Details

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalScience
Volume347
Issue number6218
Publication statusPublished - 9 Jan 2015
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 25574019

Keywords

ASJC Scopus subject areas