Electrically Controlled Click-Chemistry for Assembly of Bioactive Hydrogels on Diverse Micro- and Flexible Electrodes

Research output: Contribution to journalResearch articleContributedpeer-review



The seamless integration of electronics with living matter requires advanced materials with programmable biological and engineering properties. Here electrochemical methods to assemble semi-synthetic hydrogels directly on electronically conductive surfaces are explored. Hydrogels consisting of poly (ethylene glycol) (PEG) and heparin building blocks are polymerized by spatially controlling the click reaction between their thiol and maleimide moieties. The gels are grown as conformal coatings or 2D patterns on ITO, gold, and PtIr. This study demonstrates that such coatings significantly influence the electrochemical properties of the metal-electrolyte interface, likely due to space charge effects in the gels. Further a promising route toward engineering and electrically addressable extracellular matrices by printing arrays of gels with binary cell adhesiveness on flexible conductive surfaces is highlighted.


Original languageEnglish
Article number2200557
Pages (from-to)e2200557
JournalMacromolecular rapid communications
Issue number23
Publication statusPublished - Dec 2022

External IDs

Scopus 85135217041
WOS 000835447800001
Mendeley 672678a6-30d6-3100-8ab0-5d798285ee93


Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards


  • Hydrogels/chemistry, Click Chemistry/methods, Polyethylene Glycols/chemistry, Polymerization, Electrodes, glycosaminoglycans, microelectrodes, electrochemistry, click chemistry, hydrogels, Microelectrodes, Glycosaminoglycans, Hydrogels, Electrochemistry, Click chemistry