Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
PURPOSE: To investigate the efficacy of adjunctive selective laser trabeculoplasty (SLT) in reducing 24-h intraocular pressure (IOP) fluctuations and nocturnal IOP peaks.
METHODS: In this prospective interventional case series, 157 medically treated eyes of 157 patients with primary open-angle glaucoma (POAG) who were assigned SLT to further reduce IOP were consecutively included. Each patient had a complete glaucoma work-up and 24-h IOP monitoring (6 measurements, including one in the supine position) taken before and on average 6 months after SLT. The main outcome measures were the reduction of 24-h IOP fluctuations and nocturnal peak IOP. Secondary outcome measures were success rates, factors influencing the reduction of high 24-h IOP fluctuations and nocturnal peak IOP, complications, and severe adverse events.
RESULTS: Medicated mean 24-h IOP (mmHg) was statistically significantly reduced from 15.1 ± 2.6 to 13.8 ± 2.4 (P < 0.001) and IOP fluctuations from 6.5 ± 2.7 to 5.4 ± 2.6 (P < 0.001) 6 months after SLT. Ninety-four eyes (59.9%) initially had high IOP fluctuations (more than 5 mmHg). These were reduced from 8.1 ± 2.3 to 5.6 ± 2.7 at 6 months (P < 0.001). Fifty-two eyes (55.3%) had fluctuations below 5 mmHg post-SLT which was defined as success. Fifty-one patients (32.5%) had nocturnal IOP peaks. In these cases, nocturnal IOP was reduced by 19.2% from 20.1 ± 3.4 to 16.2 ± 3.3 mmHg at 6 months (P = 0.001).
CONCLUSIONS: The current study demonstrates that adjunctive SLT not only reduces mean 24-h IOP in treated POAG patients, but also has an additional benefit in reducing IOP fluctuations and nocturnal peak IOP.
TRIAL REGISTRATION: Clinical trial registration: NCT02959242.
Details
Original language | English |
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Pages (from-to) | 1979-1985 |
Number of pages | 7 |
Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
Volume | 261 |
Issue number | 7 |
Publication status | Published - Jul 2023 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC10271892 |
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Scopus | 85143171048 |
ORCID | /0000-0003-0829-7577/work/150330597 |
Keywords
Keywords
- Humans, Intraocular Pressure, Trabeculectomy, Glaucoma, Open-Angle/surgery, Prospective Studies, Glaucoma/surgery, Trabecular Meshwork/surgery, Laser Therapy, Lasers, Treatment Outcome