Dynamic causal modelling of evoked responses: The role of intrinsic connections

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Dynamic causal modelling is an approach to characterising evoked responses as measured by magneto/electroencephalography (M/EEG). A dynamic causal model (DCM) is a spatiotemporal, generative network model for event-related fields/responses (ERP/ERF) data. Using Bayesian model inversion, one can compute the posterior distributions of the DCM's physiological parameters and its marginal likelihood for model comparison. Model comparison can be used to test mechanistic hypotheses about how electrophysiological data were generated. In this work, we look at the relative importance of changes in intrinsic (within source) and extrinsic (between sources) connections in generating mismatch responses. In short, we introduce the modulation of intrinsic connectivity to the DCM framework. This is useful for testing hypotheses about adaptation of neuronal responses to local influences, in relation to influences that are mediated by long-range extrinsic connections (forward, backward, and lateral) from other sources. We illustrate this extension using synthetic data and empirical data from an oddball ERP experiment.

Details

Original languageEnglish
Pages (from-to)332-345
Number of pages14
JournalNeuroImage
Volume36
Issue number2
Publication statusPublished - Jun 2007
Peer-reviewedYes

External IDs

PubMed 17462916

Keywords

ASJC Scopus subject areas

Keywords

  • Dynamic causal modelling, EEG/MEG, Evoked response, Extrinsic connection, Intrinsic connections