DNA-Encoded Dynamic Combinatorial Chemical Libraries

Research output: Contribution to book/Conference proceedings/Anthology/Report › Chapter in book/Anthology/Report › Contributed › peer-review

Contributors

Abstract

DNA-encoded dynamic combinatorial chemical library (EDCCL) technology is the application of dynamic combinatorial chemistry (DCC) in the field of DNA-encoded library (DEL) technology. EDCCL technology can be used for de novo selection as well as to convert lead compounds into high-affinity bivalent binders. EDCCL technology aims to combine the advantages of DCC and DEL, while addressing some drawbacks from both.

Details

Original languageEnglish
Title of host publicationScience of Synthesis
EditorsJ. Scheuermann, Y. Li
PublisherLeipzig Georg Thieme Verlag
Chapter3.2.2.3.
Pages549-560
Number of pages12
Edition1
ISBN (electronic)9783132437357
ISBN (print)9783132455221
Publication statusPublished - May 2023
Peer-reviewedYes

Publication series

SeriesScience of Synthesis
Number5
Volume2023
ISSN2510-5469

External IDs

ORCID /0000-0003-4191-715X/work/223384765
ORCID /0000-0002-6669-4995/work/223386591

Keywords

ASJC Scopus subject areas

Keywords

  • chelate effect, DNA-encoded libraries, dual pharmacophores, dynamic combinatorial chemistry (DCC), fragment-based drug discovery