Dissociating distinct cortical networks associated with subregions of the human medial temporal lobe using precision neuroimaging

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Daniel Reznik - , Max Planck Institute for Human Cognitive and Brain Sciences (Author)
  • Robert Trampel - , Max Planck Institute for Human Cognitive and Brain Sciences (Author)
  • Nikolaus Weiskopf - , Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig University (Author)
  • Menno P. Witter - , Norwegian University of Science and Technology (Author)
  • Christian F. Doeller - , Max Planck Institute for Human Cognitive and Brain Sciences, Norwegian University of Science and Technology, Leipzig University, TUD Dresden University of Technology (Author)

Abstract

Tract-tracing studies in primates indicate that different subregions of the medial temporal lobe (MTL) are connected with multiple brain regions. However, no clear framework defining the distributed anatomy associated with the human MTL exists. This gap in knowledge originates in notoriously low MRI data quality in the anterior human MTL and in group-level blurring of idiosyncratic anatomy between adjacent brain regions, such as entorhinal and perirhinal cortices, and parahippocampal areas TH/TF. Using MRI, we intensively scanned four human individuals and collected whole-brain data with unprecedented MTL signal quality. Following detailed exploration of cortical networks associated with MTL subregions within each individual, we discovered three biologically meaningful networks associated with the entorhinal cortex, perirhinal cortex, and parahippocampal area TH, respectively. Our findings define the anatomical constraints within which human mnemonic functions must operate and are insightful for examining the evolutionary trajectory of the MTL connectivity across species.

Details

Original languageEnglish
Pages (from-to)2756-2772.e7
JournalNeuron
Volume111
Issue number17
Publication statusPublished - 6 Sept 2023
Peer-reviewedYes

External IDs

PubMed 37390820

Keywords

ASJC Scopus subject areas

Keywords

  • anatomy, area TF, area TH, brain evolution, entorhinal cortex, functional connectivity, medial temporal lobe, parahippocampal cortex, perirhinal cortex