Dishevelled paralogs in vertebrate development: Redundant or distinct?

Research output: Contribution to journalShort survey/ReviewContributedpeer-review

Contributors

Abstract

Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, expression and function of DVL isoforms have diverged between different vertebrate species. All DVL proteins share basic functionality in Wnt signal transduction. Additional, paralog-specific interactions and functions combined with context-dependent availability of DVL isoforms may play a central role in defining Wnt signaling specificity and add selectivity toward distinct downstream pathways. In this review, we recapitulate briefly cellular functions of DVL paralogs, their role in vertebrate embryonic development and congenital disease.

Details

Original languageEnglish
Article number59
JournalFrontiers in cell and developmental biology
Volume5
Issue numberMAY
Publication statusPublished - 26 May 2017
Peer-reviewedYes

External IDs

ORCID /0000-0002-4482-6010/work/142251021

Keywords

ASJC Scopus subject areas

Keywords

  • Autosomal dominant robinow, Dishevelled, Embryonic expression, Vertebrate embryonic development, Wnt signaling