Mast cells are critical initiators of neutrophil recruitment, but the molecular mechanism remains less defined. Dudeck et al. reveal that mast cell-derived tumor necrosis factor directly primes blood circulating neutrophils to license their extravasation. Here, the TNF is delivered by directional degranulation of perivascular mast cells into the bloodstream.
|Published - 9 Mar 2021
Sustainable Development Goals
- blood vessel, contact hypersensitivity, degranulation, extravasation, inflammation, mast cell, neutrophil, tumor necrosis factor