Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Mast cells are critical initiators of neutrophil recruitment, but the molecular mechanism remains less defined. Dudeck et al. reveal that mast cell-derived tumor necrosis factor directly primes blood circulating neutrophils to license their extravasation. Here, the TNF is delivered by directional degranulation of perivascular mast cells into the bloodstream.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 468-483.e5 |
| Journal | Immunity |
| Volume | 54 |
| Issue number | 3 |
| Publication status | Published - 9 Mar 2021 |
| Peer-reviewed | Yes |
External IDs
| PubMed | 33484643 |
|---|
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- blood vessel, contact hypersensitivity, degranulation, extravasation, inflammation, mast cell, neutrophil, tumor necrosis factor