DIlp7-Producing Neurons Regulate Insulin-Producing Cells in Drosophila

Research output: Contribution to journalResearch articleContributedpeer-review


  • Elodie Prince - , Biotechnology Center (BIOTEC) (Author)
  • Jenny Kretzschmar - , Biotechnology Center (BIOTEC) (Author)
  • Laura C. Trautenberg - , Biotechnology Center (BIOTEC) (Author)
  • Susanne Broschk - , TUD Dresden University of Technology (Author)
  • Marko Brankatschk - , Lipidomics of neuroglial membranes (Research Group) (Author)


Cellular Insulin signaling shows a remarkable high molecular and functional conservation. Insulin-producing cells respond directly to nutritional cues in circulation and receive modulatory input from connected neuronal networks. Neuronal control integrates a wide range of variables including dietary change or environmental temperature. Although it is shown that neuronal input is sufficient to regulate Insulin-producing cells, the physiological relevance of this network remains elusive. In Drosophila melanogaster, Insulin-like peptide7-producing neurons are wired with Insulin-producing cells. We found that the former cells regulate the latter to facilitate larval development at high temperatures, and to regulate systemic Insulin signaling in adults feeding on calorie-rich food lacking dietary yeast. Our results demonstrate a role for neuronal innervation of Insulin-producing cells important for fruit flies to survive unfavorable environmental conditions.


Original languageEnglish
Article number630390
JournalFrontiers in physiology
Publication statusPublished - 27 Jul 2021


ASJC Scopus subject areas


  • AKT, diet, heat resistance, insulin signaling, metabolism