All-glass systems such as mobile glass partition walls and all-glass doors set high requirements for transparency, lightness and durability. The interconnection between the panels is conventionally per-formed by eye-catching fittings and clamping details. Hence, innovative glass–plastic-composite pan-els, consisting of a systematic combination of a polymer Polymethylmethacrylate (PMMA) interlayer core and cover layers of thin glass, are currently under development. The units show high-perfor-mance load-bearing behaviour and exhibit full transparency at low panel self-weight. Additionally, the novel composite allows for the implementation of a direct connection with the supporting structure into the PMMA interlayer core. These novel construction types will allow for small as well as unobtru-sive connection details, which lead to the desired maximum transparency of all-glass systems. Differ-ent connection joints such as fastened and bonded types were developed and tested with a focus on applications in all-glass systems for the building industry. In this paper, the development process, and experimental results for different connection joints with glass and stainless-steel substrates, tested under tensile and shear loading, are presented and dis-cussed. For bonded joints, three transparent structural adhesives are included in the experimental program: UV acrylate, 2-C epoxy resin and 2-C polyurethane. Furthermore, the investigations con-sider detachable fastened connections. Based on the development and experimental evaluation of the mechanical load-bearing behaviour, the design of an ultra-lightweight segmented glass arch adopting novel glass–plastic-composite panels and associated connections for the presentation at the special show “glass technology live” at the glasstec international trade fair is presented. The re-sults from this development form the basis for further investigations and an advanced design of con-nection details for the edge of glass-plastic-composites.