Deterioration without replenishment--the misery of oocyte cohesin

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Humans suffer a steep increase in aneuploidies when oocytes age, and deterioration of cohesin was suggested recently as a prominent cause. In the November 15, 2010, issue of Genes & Development, Tachibana-Konwalski and colleagues (pp. 2505-2516) answered a question central to this hypothesis: Can cohesin be reloaded onto mouse oocyte chromosomes long after birth? They found that it cannot, or at least not with an efficiency adequate to rescue cohesin deficiency. With no chance for sufficient replenishment, age-related loss of sister chromatid cohesion seems unavoidable.

Details

Original languageEnglish
Pages (from-to)2587-91
Number of pages5
JournalGenes and Development
Volume24
Issue number23
Publication statusPublished - 1 Dec 2010
Peer-reviewedYes

External IDs

PubMed 21123645
PubMedCentral PMC2994032
Scopus 78649868630

Keywords

Keywords

  • Age Factors, Aneuploidy, Animals, Cell Cycle Proteins/metabolism, Chromosomal Proteins, Non-Histone/metabolism, Female, Gene Expression Regulation, Humans, Male, Mice, Oocytes/metabolism