Depression and anxiety in women with malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST): an analysis of the AGO-CORSETT database

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • M. Bossart - , University of Freiburg (Author)
  • H. Plett - , University of Duisburg-Essen (Author)
  • B. Krämer - , University of Tübingen (Author)
  • E. Braicu - , Charité – Universitätsmedizin Berlin (Author)
  • B. Czogalla - , Ludwig Maximilian University of Munich (Author)
  • M. Klar - , University of Freiburg (Author)
  • S. Singer - , Johannes Gutenberg University Mainz (Author)
  • D. Mayr - , Ludwig Maximilian University of Munich (Author)
  • A. Staebler - , University of Tübingen (Author)
  • A. du Bois - , University of Duisburg-Essen (Author)
  • S. Kommoss - , University of Tübingen (Author)
  • T. Link - , Department of Gynecology and Obstetrics (Author)
  • A. Burges - , Ludwig Maximilian University of Munich (Author)
  • F. Heitz - , University of Duisburg-Essen (Author)
  • M. Grube - , University of Tübingen (Author)
  • F. Trillsch - , Ludwig Maximilian University of Munich (Author)
  • P. Harter - , University of Duisburg-Essen (Author)
  • P. Wimberger - , Department of Gynecology and Obstetrics (Author)
  • P. Buderath - , University of Duisburg-Essen (Author)
  • A. Hasenburg - , Johannes Gutenberg University Mainz (Author)

Abstract

Introduction: The intention of this study was to evaluate the level of anxiety and depression of malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) survivors and to identify possible alterable cofactors. Methods: CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO Studygroup. Women who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Hospital Anxiety and Depression Scale (HADS) to evaluate distress. Predictors of distress (type of surgery, chemotherapy, time since diagnosis, recurrence, second tumor, pain) were investigated using multivariate linear regression analysis. Results: 150 MOGCT and SCST patients with confirmed histological diagnosis completed the questionnaire median seven years after diagnosis. They had a HADS total score ≥ 13 indicating severe mental distress in 34% of cases. Patients after fertility-conserving surgery had lower probability of severe mental distress than those without fertility-conserving treatment (β = − 3.1, p = 0.04). Pain was associated with the level of distress in uni- and multivariate analysis (coef 0.1, p < 0.01, coef. Beta 0.5). Discussion: Severe mental distress was frequent in patients with MOGCT and SCST and the level of pain was associated with the level of distress. Fertility conserving therapy, however, was associated with less mental distress. Screening and treatment of pain and depression is required to improve mental well-being in survivors of MOGCT and SCST.

Details

Original languageEnglish
Pages (from-to)1155-1162
Number of pages8
JournalArchives of gynecology and obstetrics
Volume307 (2023)
Issue number4
Publication statusPublished - Apr 2023
Peer-reviewedYes

External IDs

PubMed 36127525

Keywords

ASJC Scopus subject areas

Keywords

  • Anxiety, Depression, Fertility-sparing surgery, Ovarian germ cell tumors, Pain, Sex cord stromal tumors, Germ Cells/pathology, Prospective Studies, Anxiety/epidemiology, Humans, Neoplasms, Germ Cell and Embryonal/complications, Sex Cord-Gonadal Stromal Tumors/epidemiology, Female, Retrospective Studies, Ovarian Neoplasms/pathology

Library keywords